Case report reveals Ewing sarcoma mimicking melanoma in a nail unit, suggesting diagnostic difficulties.
Background: Ewing sarcoma is an aggressive malignant small round cell tumor classically arising in bone and deep soft tissues of children and young adults. Although it predominantly involves the long bones and pelvis, extraskeletal presentations are increasingly recognized and may pose significant diagnostic challenges, particularly in uncommon anatomical sites. Cutaneous and superficial soft tissue variants represent a small subset of the Ewing sarcoma family of tumors, and their clinical manifestations often mimic benign or inflammatory conditions, resulting in delayed diagnosis.
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Uzunçakmak et al. (2026) studied this question.
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