Cost-effectiveness analysis reveals capivasertib plus fulvestrant lacks cost efficiency in HR+/HER2− breast cancer, suggesting significant price reductions are needed.
Despite clinical benefits, capivasertib plus fulvestrant was not cost effective at current price from a U.S. payer's perspective. The cost of capivasertib per 4 weeks would be required to decrease by ∼80% from $28,332 to $5,598 (about $87 per 200 mg) to meet the WTP threshold of $150,000.
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Liang et al. (2026) studied this question.
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