This review summarizes advancements in mRNA nanotherapeutics for sepsis, highlighting immunomodulation and delivery challenges.
This review summarizes recent advances in mRNA-based nanotherapeutics for sepsis, with a focus on delivery strategies, immunomodulatory mechanisms, and translational potential. Key challenges related to delivery efficiency, safety, and regulatory considerations are discussed. Finally, future directions are proposed for the development of individualized, stage-specific mRNA nanotherapies aimed at restoring immune homeostasis in critically ill patients.
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Liu et al. (2026) studied this question.
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