Key result
Higher uric acid to HDL-cholesterol ratio is linked to increased diabetic kidney disease in T2D and NAFLD.
Why the study?
Is a higher uric acid to HDL-cholesterol ratio associated with diabetic kidney disease in individuals with type 2 diabetes and NAFLD?
Is a higher uric acid to HDL-cholesterol ratio associated with diabetic kidney disease in individuals with type 2 diabetes and NAFLD?
Higher uric acid to HDL-cholesterol ratio is associated with increased odds of diabetic kidney disease in patients with concurrent type 2 diabetes and NAFLD.
Higher UHR was associated with higher odds of DKD in individuals with T2DM and NAFLD. Nevertheless, given the cross-sectional design, the single eGFR-based outcome definition in NHANES, and the differing kidney outcome definitions between cohorts, the findings should be interpreted cautiously and confirmed in prospective studies.
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Gong et al. (2026) studied this question. A higher uric acid to HDL-cholesterol ratio was associated with higher odds of diabetic kidney disease in individuals with type 2 diabetes and NAFLD.
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