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April 1, 2026The Journal of ArthroplastyOpen Access

Periarticular Injection for Pain Control after Surgical Treatment of Knee Periprosthetic Joint Infection

George A. Shultz Alicia M. Williams Levent A. Ozdemir Eric R. Siegel C. Lowry Barnes Simon C. Mears Benjamin M. Stronach Jeffrey B. Stambough

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Key Points

This study evaluates the safety and effectiveness of periarticular injection for pain management in knee periprosthetic joint infection surgeries.
Conducted a retrospective review of 309 patients with knee PJI treated surgically.
Compared outcomes between 121 patients who received intraoperative periarticular injection and 188 controls without it.
Recorded postoperative pain scores and opioid consumption at 24, 48, and 72 hours post-surgery.
No significant difference in reinfection rates at 12 months (5.0% with PAI vs. 8.0% without, P = 0.30).
PAI group had lower pain scores at 24 hours (5.53 vs. 5.71, P < 0.001) and 48 hours (5.35 vs. 5.64, P = 0.042).
Patients receiving PAI required significantly less morphine milligram equivalents (90.2 vs. 130.4 MME, P = 0.0036).

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Implication

Retrospective review shows intraoperative periarticular injection lowers pain in knee PJI, suggesting safety in procedures.

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Cite This Study

Shultz et al. (2026) studied this question.

synapsesocial.com/papers/69e9b71b85696592c86eb27d https://doi.org/10.1016/j.arth.2026.04.056

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