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April 1, 2026Journal of InfectionOpen Access

Host response profiling reveals heterogenous immune responses in hospitalised adults with respiratory viral detection

Alex Tanner Bilge Eylem Dedeoglu Nathan J. Brendish Rebecca W M Wong Irfaan Maan Tristan W Clark

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Key Points

The aim is to identify the diversity of immune responses in adults with viral acute respiratory infections.
Utilized PCR to detect respiratory viruses in hospitalized adults.
Assessed host gene expression to evaluate immune responses.
Combined pathogen testing with host response analysis for improved interpretation.
Found heterogeneous immune responses linked to different respiratory viruses.
Highlighted the need for careful interpretation of viral causality in ARI cases.
Indicated that combined testing may reduce unnecessary antibiotic prescriptions.

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Implication

This analysis shows varying immune responses in hospitalized adults with viral respiratory infections, suggesting better diagnosis strategies.

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Cite This Study

Tanner et al. (2026) studied this question.

synapsesocial.com/papers/69e9b77885696592c86eb3fb https://doi.org/10.1016/j.jinf.2026.106750

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