Why the study?
Does atypical antipsychotic treatment increase f(QRS-T) angle in children and adolescents?
Does atypical antipsychotic treatment increase f(QRS-T) angle in children and adolescents?
f(QRS-T) may serve as a complementary electrocardiographic marker alongside QTc for cardiac safety monitoring in pediatric patients on atypical antipsychotics.
Urges caution beyond QTc in cardiac monitoring of pediatric patients on atypical antipsychotics; leaves open f(QRS-T) as complementary repolarization marker.
f(QRS-T) is significantly increased in children and adolescents receiving atypical antipsychotics and is associated with QTc prolongation, although it is not independently predicted by treatment duration or conventional QT-based indices. These findings suggest that f(QRS-T) may serve as a complementary electrocardiographic marker of repolarization heterogeneity alongside QTc in the cardiac safety monitoring of pediatric patients treated with atypical antipsychotics.
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Asena et al. (2026) studied this question.
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