Background Mechanical ventilation (MV) is a life‑saving intervention for patients unable to maintain adequate oxygenation or ventilation. However, MV is also associated with complications such as ventilator‑associated pneumonia, lung injury, and prolonged ICU stay, which may increase morbidity and mortality. Previous studies in Ethiopia and the region are limited and do not fully address key predictors of clinical outcomes among mechanically ventilated patients. Objective: To assess clinical outcomes and associated factors among mechanically ventilated patients in adult intensive care units at Jimma Medical Center, Southwest Ethiopia, and in2024. Methods A retrospective cross‑sectional study was conducted among 411 randomly selected medical records of mechanically ventilated adult patients. Data were extracted using a structured and pretested tool. Statistical analysis included bivariable and multivariable logistic regression. Variables with p 5 days before intubation (AOR = 3.03, 95% CI: 1.05–6.09), re‑intubation (AOR = 9.02, 95% CI: 4.07–20.01), presence of comorbidities (AOR = 9.12, 95% CI: 4.38–18.99), development of complications (AOR = 6.84, 95% CI: 3.15–14.81), multi‑organ dysfunction syndrome (MODS) (AOR = 3.48, 95% CI: 1.47–7.82), and use of sedation (AOR = 0.36, 95% CI: 0.18–0.74). Conclusion Mechanically ventilated patients at Jimma Medical Center experience a high mortality rate. Key determinants of mortality were re‑intubation, comorbidities, complications, MODS, and delayed intubation. Improving ICU protocols, early identification of high‑risk patients, proper monitoring, and prevention of unplanned extubation may improve survival outcomes.
Uma et al. (Tue,) studied this question.