Recent findings reveal how distinct pathways in the basal ganglia influence movement by modulating dopamine release in striosomes, suggesting new roles for these pathways.
The GABAergic striatal outputs forming the direct and indirect pathways of the basal ganglia (BG), classically defined by Drd1 and Drd2 expression, respectively, are crucial in the control of voluntary movement. Recent evidence has identified parallel direct and indirect pathways within striosomes, that exert opposing control over striatal DA release and thereby influencing locomotor behavior. These findings refine our understanding of how discrete BG pathways coordinate voluntary actions.
No takes yet. Share an insight, caveat, or question.
Rocha et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: