What question did this study set out to answer?

The study aims to investigate how emotion processing and regulation affect connectivity between prefrontal areas and the amygdala in social anxiety disorder.

April 23, 2026The British Journal of Psychiatry1 citationsOpen Access

Altered prefrontal effective connectivity during emotion regulation in social anxiety disorder

ESElisabeth Schrammen AJAlec J. Jamieson HMHannah Meinert

Key Points

The study aims to investigate how emotion processing and regulation affect connectivity between prefrontal areas and the amygdala in social anxiety disorder.
Analyzed effective connectivity between brain regions during emotion regulation tasks.
Employed neuroimaging techniques to evaluate prefrontal-amygdala interactions.
Compared connectivity patterns in individuals with social anxiety disorder and healthy controls.
Identified significant differences in intra-prefrontal connectivity among individuals with social anxiety disorder.
Found that aberrant emotion regulation is more closely related to intra-prefrontal circuits than to amygdala-prefrontal connectivity.
Demonstrated a feedback-driven influence of emotion processing on connectivity in the brain.

Abstract

The results support the idea that emotion processing and regulation influence connectivity between prefrontal areas and the amygdala in a complex, feedback-driven manner. Our findings suggest that aberrant emotion regulation in social anxiety disorder appears to be more closely linked to differences in intra-prefrontal circuits than deficits in amygdala-prefrontal connectivity.

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Cite This Study

Schrammen et al. (Tue,) studied this question.

synapsesocial.com/papers/69e9b85585696592c86eb97c https://doi.org/https://doi.org/10.1192/bjp.2026.10628

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