Knockdown of ADAMTS2 mitigates inflammation and barrier dysfunction in acute respiratory distress syndrome, suggesting potential therapies.
ADAMTS2 knockdown mitigated LPS-induced epithelial injury and barrier dysfunction, in association with PI3K/AKT/mTOR signaling and autophagy-related changes, suggesting ADAMTS2 as a potential therapeutic target for ARDS pending further in vivo validation.
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Gao et al. (2026) studied this question.
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