Pd-catalyzed reaction produces 5-methylene cyclopentenones in high yields, suggesting a practical approach for synthetic chemistry.
We report a Pd-catalyzed oxidative carbonylative carbocyclization of enallenes that affords 5-methylene cyclopentenones in high yields with excellent regio- and stereoselectivity. The reaction proceeds through olefin-directed allenylic C(sp³)-H activation, and ligand control enables site-selective transformation of unsymmetrical enallenes, favoring the larger alkyl substituent over methyl (up to 20:1). A broad substrate scope and compatibility with heterogeneous Pd-AmP-MCF catalysis and biomimetic aerobic oxidation underscore the practicality and sustainability of the method.
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Wang et al. (2026) studied this question.
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