Pediatric lynch syndrome reveals advanced left-sided colorectal cancer patterns, suggesting unique biology in this age group.
LS confers risk for pediatric colorectal adenoma and cancer. CRC in this population manifests predominantly as left-sided, advanced-stage CRC, driven by loss-of-function variants in MLH1 and MSH2. These findings contrast with the right-sided predominant adult LS and suggest age-specific biology. Increased awareness and further research are needed to inform age-appropriate surveillance strategies.
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Phen et al. (2026) studied this question.
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