Strategies Toward Accessing Enantioenriched (Hetero)Benzo‐Fused 5‐ and 6‐ Membered Rings via Intermolecular Carbometalation

ABSTRACT Enantioenriched benzofused 5‐ and 6‐ membered rings continue to be found as notable motifs in important molecules such as pharmaceuticals and natural products. A key synthetic strategy towards accessing these structures is via a metal‐catalyzed intermolecular carbometalation step across a substituted olefin or alkyne. This review emphasizes recent advances towards accessing enantioenriched benzofused 5‐ and 6‐ membered rings via intermolecular carbometalation strategy, catalyzed by late and early transition metals. Through covering the key mechanistic investigations and computed conformational analyses, this review hopes to allow for a more unified understanding of how asymmetric control is attained across a diverse array of metals and ligands, and to highlight significant advances made in the past decade.