Observational study assesses infection risks from live vaccination in young patients on sirolimus, suggesting low risks.
In young patients with VA receiving sirolimus, live vaccine-associated infection risk appears low and comparable to rates in solid organ transplant recipients on immunosuppression. Immunologic evaluation may help identify those at higher risk, though most tolerated vaccination without adverse events. Our practice prioritizes varicella vaccination first, given the availability of effective treatment for potential complications.
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Merkle et al. (2026) studied this question.
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