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April 23, 2026Liver International2 citationsOpen Access

Albumin Restores Endothelial Cell Mitochondrial Morphology in Patients With Decompensated Cirrhosis

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SFSusan E. FischerRPRudmer J. PostmaRBRoel Bijkerk

Key Points

  • To evaluate the effects of albumin on endothelial cell mitochondrial morphology in patients with decompensated cirrhosis.
  • Analyzed plasma from patients with decompensated cirrhosis and hypoalbuminemia.
  • Observed morphological changes in endothelial cells and their mitochondria.
  • Assessed the effect of albumin on mitochondrial function.
  • Hypoalbuminemia was associated with significant changes in endothelial mitochondrial morphology.
  • Albumin treatment mitigated these morphological changes.
  • Results support the therapeutic potential of albumin in vascular dysfunction in cirrhosis.

Abstract

Plasma from patients with DC and hypoalbuminemia induces EC morphological changes, particularly in mitochondria. Albumin mitigates these effects, suggesting a direct modulatory role on mitochondrial function and supporting its therapeutic potential in vascular dysfunction in cirrhosis.

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Cite This Study

Fischer et al. (2026) studied this question.

synapsesocial.com/papers/69e9bb2285696592c86ecf96https://doi.org/10.1111/liv.70653
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