Quantitative analysis shows CD79B depletion indicates accelerated B cell progenitor aging, suggesting new biomarkers for aging assessment.
We previously demonstrated that age-related dysfunction in lipid synthesis pathways is associated with impaired B cell progenitor development in mice and humans. Here, we describe an optimized protocol for the quantification of CD79B, a novel biomarker of accelerated aging identified in our multi-omics immune aging study. Flow cytometric analyses of immune cell subpopulations revealed selective depletion of CD19 + CD79B + lymphoid progenitors in bone marrow from aged mice and accelerated aging models, phenocopying advanced physiological aging in humans. Thus, this detailed protocol provides a validated platform to interrogate novel biomarkers of hematopoietic stem and progenitor cell dysfunction associated with systemic aging
No takes yet. Share an insight, caveat, or question.
Vicenzi et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: