Key result
Severe CHD in noncardiac surgery is linked to a ~7-fold higher mortality risk in children.
Why the study?
Advances in diagnosis and treatment have increased life expectancy in children with CHD, leading to more requiring noncardiac surgery, but comparative post-operative outcomes are unclear.
Does the presence of congenital heart disease increase the risk of mortality and major adverse post-operative outcomes in children undergoing noncardiac surgery?
Cohort (n=51,008)
Yes
Does the presence of congenital heart disease increase the risk of mortality and major adverse post-operative outcomes in children undergoing noncardiac surgery?
Odds Ratio: 7.32 (95% CI 2.83–18.9)
Absolute Event Rate: 8.2% vs 1.2%
p-value: p=<0.001
Children with major and severe congenital heart disease undergoing noncardiac surgery have a significantly increased risk of mortality compared to matched children without CHD.
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Prompts heightened perioperative vigilance in severe pediatric CHD; leaves open optimal risk mitigation pending prospective trials.
Faraoni et al. (2016) conducted a cohort in Congenital heart disease in children undergoing noncardiac surgery (n=51,008). Severe congenital heart disease vs. No congenital heart disease was evaluated on Overall mortality (OR 7.32, 95% CI 2.83-18.90, p=<0.001). Severe congenital heart disease in children undergoing noncardiac surgery was associated with significantly higher overall mortality compared to matched controls (8.2% vs 1.2%; OR 7.32, 95% CI 2.83-18.90; p<0.001).
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