Based on clinical observations and the increasing number of published reports, it is evident that many feline immunodeficiency virus (FIV)-positive cats display mild or inapparent clinical signs and frequently achieve normal life spans. Although the clinical manifestation of infection is determined by unknown viral, host, and environmental factors, the relative intrahost genetic stability of FIV may play an important role in the apparent clinical stability observed in many naturally infected cats. Performance of the commercial Fel-O-Vax FIV vaccine documented in recent field studies is suboptimal, reminding us that the fully efficacious lentiviral vaccine remains elusive.
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Bęczkowski et al. (2022) studied this question.
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