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April 24, 2026Translational Oncology0 citationsOpen Access

Single-Cell sequencing investigation of endoplasmic reticulum stress-related genes in gastric cancer prognostic models and identification of NOX5 as a novel therapeutic target

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YFYue FanTaiyuan Central HospitalFLfeng liuHZHuijun ZuoTaiyuan Central Hospital

Key Points

  • This research aims to explore endoplasmic reticulum stress-related genes and their role in gastric cancer prognosis.
  • Single-cell sequencing was conducted to analyze ERS-related genes.
  • Prognostic models were built based on the identified gene signatures.
  • The ERS-related signature is identified as a reliable prognostic marker for gastric cancer.
  • NOX5 is proposed as a promising new target for therapy.

Abstract

The ERS-related signature is a promising independent prognostic and predictive biomarker for GC. NOX5 represents a novel potential therapeutic target.

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Cite This Study

Fan et al. (2026) studied this question.

synapsesocial.com/papers/69eb07a4553a5433e34b31a4https://doi.org/10.1016/j.tranon.2026.102780
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