Key result
Systematic review protocol outlines planned evaluation of self-management interventions for cancer therapy-induced cardiotoxicity.
Why the study?
Cancer therapy-induced cardiotoxicity impacts survivor quality of life, but little is known regarding the effectiveness of self-management strategies and no systematic review currently exists.
Do self-management interventions reduce cancer therapy-induced cardiotoxicity in cancer survivors?
Systematic Review
Do self-management interventions reduce cancer therapy-induced cardiotoxicity in cancer survivors?
This systematic review protocol outlines a methodology to evaluate the effectiveness of self-management interventions in mitigating cancer therapy-induced cardiotoxicity and improving cardiovascular health in cancer survivors.
May support self-management to preserve CV health in cancer survivors; leaves open confirmation in higher-quality trials before changing practice.
Background Advancements in cancer treatments, such as chemotherapy and radiotherapy, have increased survival rates. However, these treatments have side effects, such as cardiotoxicity, which significantly impact cancer survivors’ cardiovascular health and quality of life (QoL). Thus far, despite a limited amount of related literature, preliminary evidence suggests that patients can benefit from self-management. This systematic review aims to explore the effectiveness of self-management interventions in managing cancer therapy-induced cardiotoxicity and improving cardiovascular health and QoL. Methods Two reviewers will independently appraise, extract, and synthesize data from eligible studies published in the last 20 years (January 2004 to November 2024) obtained through comprehensive literature searches in databases, including CINAHL, PubMed, Web of Science, Cochrane CENTRAL, PsycINFO, and EMBASE. Only English-language studies will be included. Study quality will be assessed using the JBI appraisal tool. Studies will be pooled in a statistical meta-analysis using software R 4.3.3 or summarized in narrative format. The certainty of the evidence will be graded using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach. Discussion Despite the high risk of cardiovascular disease (CVD) associated with cancer treatment, little is known about the effectiveness of self-management strategies on improving cancer therapy-induced cardiotoxicity. Currently, there is no systematic review or structured guidance focused on self-management for cancer survivors. This review aims to evaluate the effectiveness of self-management interventions in managing cancer therapy-induced cardiotoxicity and improving cardiovascular health in cancer survivors. Systematic review registration PROSPERO CRD42024621854.
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Yang et al. (2026) conducted a systematic review in Cancer therapy-induced cardiotoxicity. Self-management interventions vs. Standard care, usual care, no intervention, or alternative interventions was evaluated on Cardiotoxicity (clinical syndromes, imaging-based measures, or functional impairment measures). Self-management interventions for managing cancer therapy-induced cardiotoxicity will be evaluated in this systematic review protocol, which currently contains no clinical results.
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