Diastereoselective Synthesis of β-Hydroxy Allylic Tertiary Sulfides via Nickel/Photoredox Cooperative Catalysis

Heyang Xu; Zhixian Wu; Jing‐Ran Shan; Lei Shi

doi:10.1039/d6cc01783e

January 1, 2026Chemical Communications

Diastereoselective Synthesis of β-Hydroxy Allylic Tertiary Sulfides via Nickel/Photoredox Cooperative Catalysis

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Key Points

The study aims to develop an effective synthesis method for β-hydroxy allylic sulfides to overcome existing challenges.
Utilized a nickel/photoredox cooperative catalysis system
Focused on improving the diastereoselectivity
Addressed issues related to sulfur-mediated catalyst poisoning
Achieved successful diastereoselective synthesis of β-hydroxy allylic sulfides
Demonstrated overcoming catalyst poisoning issues
Indicated enhanced control over stereochemistry in the synthesized products

Implication

This research demonstrates a new synthetic method for β-hydroxy allylic sulfides, suggesting improved stereocontrol in complex molecules.

Abstract

β-Hydroxy allylic sulfides represent privileged motifs in bioactive molecules but remain challenging to synthesize owing to sulfurmediated catalyst poisoning and stereocontrol issues. We report a nickel/photoredox cooperative catalysis system for...

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Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/69eb08ef553a5433e34b3a08 https://doi.org/10.1039/d6cc01783e

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Diastereoselective Synthesis of β-Hydroxy Allylic Tertiary Sulfides via Nickel/Photoredox Cooperative Catalysis

Key Points

Implication

Abstract

Discussion

Cite This Study

Diastereoselective Synthesis of β-Hydroxy Allylic Tertiary Sulfides via Nickel/Photoredox Cooperative Catalysis

Key Points

Implication

Abstract

Discussion

Cite This Study

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