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Evaluate how donor characteristics and recipient spleen function affect red blood cell transfusion survival in sickle cell disease.

April 24, 2026Blood AdvancesOpen Access

Red cell transfusion survival in sickle cell disease is reduced by donor characteristics and recipient spleen activity

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Evaluate how donor characteristics and recipient spleen function affect red blood cell transfusion survival in sickle cell disease.
Conducted an observational clinical trial in patients with sickle cell disease receiving chronic transfusion therapy.
Used biotin-labeling to measure the lifespan of transfused red blood cells over 16 weeks.
Analyzed recipient spleen volume and donor characteristics, like G6PD activity, through various assessments.
Median post-transfusion recovery was 97.3% at 24 hours, 80% at 28 days, and 21% at 90 days.
Decreased survival of transfused red blood cells was linked to recipient spleen volume and donor G6PD deficiency or alpha-thalassemia trait.
Recipient RBC alloimmunization had a non-significant association with reduced RBC survival.

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Observational trial reveals donor traits reduce red blood cell survival in sickle cell disease, suggesting implications for treatment.

Yee et al. (2026) studied this question.

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