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Assess the effect of SGLT2 inhibitors on clinical outcomes in diabetes mellitus patients after heart transplantation.

April 24, 2026Diabetes Therapy0 citationsOpen Access

Impact of SGLT2 Inhibitors on Clinical Outcomes in Patients with Diabetes Mellitus Following Heart Transplantation: A Meta-analysis

HWHong WangThe People's Hospital of Guangxi Zhuang Autonomous Region XXXiaoya XieMacau University of Science and Technology GGGuoping GongThe First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine

Key Points

Assess the effect of SGLT2 inhibitors on clinical outcomes in diabetes mellitus patients after heart transplantation.
Performed a meta-analysis of existing studies on SGLT2 inhibitors and heart transplantation outcomes.
Evaluated data on rejection rates and mortality in the context of diabetes mellitus.
SGLT2 inhibitors significantly reduced rejection rates in patients with diabetes following heart transplantation.
The impact on mortality remains unclear and requires further research.

Abstract

In participants with DM following HT, SGLT2 inhibitors significantly reduced rejection post transplantation. However, its impact on other important clinical outcomes, including mortality, should be further assessed with more data in future studies.

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