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Findings reveal potential links between PPAR-γ and executive function in adolescents with MDD, suggesting further exploration is needed.
Higher PPAR-γ levels may be associated with a potentially compensatory or neuroprotective pattern, particularly in adolescents with MDD, whereas the inverse correlations observed in the MDD-PF group may indicate a different or disrupted regulatory pattern in more severe presentations. Overall, PPAR-γ may be linked to executive functioning in adolescent depression, warranting confirmation in larger longitudinal studies.
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Karaca et al. (2026) studied this question.
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