RCSA-Based Relative Stereochemical Analysis for Polar Molecules in PBLG Liquid Crystalline Medium

Qi Chang; Mikhail Reibarkh; Xiao Lu Wang

doi:10.1039/d6cc01145d

January 1, 2026Chemical Communications

RCSA-Based Relative Stereochemical Analysis for Polar Molecules in PBLG Liquid Crystalline Medium

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Key Points

To analyze the stereochemistry of polar molecules using RCSA in PBLG medium.
Utilized ¹³C RCSA for analysis in a commercial PBLG medium.
Introduced THF-d₈ and THF-d₈/DMSO-d₆ solvent systems to improve solubility.
Compared effectiveness against CDCl₃ solvent limitations.
Successfully enabled polar molecule analysis in PBLG without solubility issues.
Demonstrated that THF-d₈ and DMSO-d₆ solvents provided better compatibility.
Confirmed improved stereochemical resolution for targeted compounds.

Implication

Research examines stereochemical analysis for polar molecules using RCSA in PBLG, suggesting enhanced solubility.

Abstract

¹³C RCSA-based stereochemical analysis in commercially available PBLG medium is enabled for polar molecules by introducing THF-d₈ and THF-d₈/DMSO-d₆ solvent systems. This overcomes solubility limitations of CDCl₃, which had been...

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Cite This Study

Chang et al. (2026) studied this question.

synapsesocial.com/papers/69eb099a553a5433e34b3f66 https://doi.org/10.1039/d6cc01145d

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RCSA-Based Relative Stereochemical Analysis for Polar Molecules in PBLG Liquid Crystalline Medium

Key Points

Implication

Abstract

Discussion

Cite This Study

RCSA-Based Relative Stereochemical Analysis for Polar Molecules in PBLG Liquid Crystalline Medium

Key Points

Implication

Abstract

Discussion

Cite This Study

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