A cross-sectional study on the impact of early systematic antidepressant therapy on positive/negative affect and impulsivity in euthymic bipolar disorder patients
Cross-sectional study assesses antidepressant effects on affect and impulsivity in bipolar disorder patients, indicating careful prescription is essential.
Key Points
The study aims to evaluate the effects of early systematic antidepressant therapy on impulsivity and positive/negative affect in euthymic bipolar disorder patients.
Cross-sectional analysis involving 124 Han Chinese bipolar disorder patients
Participants divided into two groups: systematic antidepressant treatment (AT) and no treatment (NT)
Measured outcomes included Positive and Negative Affect Scale and Barratt Impulsiveness Scale; statistical analyses applied.
AT group showed higher levels of negative affect and various impulsivity metrics compared to NT group
No significant difference in positive affect or motor impulsivity was observed
Negative affect did not mediate the relationship between antidepressant treatment and impulsivity.