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April 22, 2026JAMA Network OpenOpen Access

Absence of SARS-CoV-2 in Placental Tissue After Maternal COVID-19

Shelli Farhadian Benjamin Orlinick Kristin M. Milano Dilgash Mekael Harvey J. Kliman

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Key Points

This research aimed to determine if SARS-CoV-2 persists in placental tissue after maternal infection during COVID-19.
Conducted a case-control study comparing placental tissues from infected and non-infected mothers.
Analyzed presence of SARS-CoV-2 protein and RNA in the samples.
No SARS-CoV-2 protein or RNA detected in placental tissues from mothers who had COVID-19.
Findings suggest that SARS-CoV-2 does not persist in placental tissue post-infection.

Implication

Case-control study examines SARS-CoV-2 presence in placental tissue after maternal COVID-19, indicating no persistence.

Abstract

This case-control study examines whether SARS-CoV-2 protein or RNA persists in placental tissue following maternal COVID-19 infection.

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Cite This Study

Farhadian et al. (2026) studied this question.

synapsesocial.com/papers/69eb0a66553a5433e34b477c https://doi.org/10.1001/jamanetworkopen.2026.8567

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Persistence of SARS‐CoV‐2 RNA Residues in Placenta Tissue Following Maternal COVID‐19 Infection During PregnancyOriginal Research · 2026
2Pregnancy Loss Associated with COVID-19 Infection: Associations with Detection of Viral RNA in Placental and Fetal Tissue2025
3SARS-CoV-2 replicates in the placenta after maternal infection during pregnancy2024 · 20 citations
4Histopathological and clinical analysis of COVID-19-infected placentas2024 · 6 citations
5Placental SARS-CoV-2 Infection and Its Implications for Increased Risk of Adverse Pregnancy Outcomes2024 · 2 citations

More related papers

In Situ Analyses of Placental Inflammatory Response to SARS-CoV-2 Infection in Cases of Mother–Fetus Vertical Transmission2024
Histopathological Findings in Placenta Delivered from SARS-CoV2 Positive Mothers2025
Presence of SARS-CoV-2 in fetal organs via intraamniotic infection2025

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