Low lysosomal acid lipase activity is associated with histological progression of metabolic dysfunction-associated steatotic liver disease

Rosa Lombardi; Felice Cinque; Annalisa Cespiati; C. Bertelli; Giuseppina Pisano; Giovanna Oberti; E. Fatta; Jaqueline Currà; Emma Calzavara; Francesca Alletto; C Garavaglia; Giulia Cincotto; Anna Ludovica Fracanzani; Monica Gomaraschi

doi:10.1007/s12072-026-11084-6

April 22, 2026Hepatology InternationalOpen Access

Low lysosomal acid lipase activity is associated with histological progression of metabolic dysfunction-associated steatotic liver disease

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Key Points

This research investigates the link between lysosomal acid lipase activity and histological progression in metabolic dysfunction-associated steatotic liver disease.
Measured lysosomal acid lipase (LAL) activity in MASLD patients.
Assessed risk of histological progression with LAL/ptls ratio.
Evaluated findings alongside non-invasive tools.
Lower LAL/ptls ratio indicates higher risk of histological progression in MASLD.
Findings support LAL as a complementary tool to non-invasive assessments.
Suggests LAL activity reflects important biological pathways related to inflammation.

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Implication

Analysis reveals low lysosomal acid lipase activity increases risk of liver disease progression, indicating potential for early intervention.

Abstract

Lower LAL/ptls ratio identifies MASLD patients at increased risk of histological progression and complements non-invasive tools by reflecting biological pathways linked to inflammation.

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Cite This Study

Lombardi et al. (2026) studied this question.

synapsesocial.com/papers/69eb0a66553a5433e34b4811 https://doi.org/10.1007/s12072-026-11084-6

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Low lysosomal acid lipase activity is associated with histological progression of metabolic dysfunction-associated steatotic liver disease

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Low lysosomal acid lipase activity is associated with histological progression of metabolic dysfunction-associated steatotic liver disease

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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