Divergent patterns of cognitive decline in preclinical Alzheimer's disease: Implications for secondary prevention trials

April 1, 2026Alzheimer s & DementiaOpen Access

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Key Points

This research aims to explore patterns of cognitive decline in preclinical Alzheimer's disease to enhance prevention strategies.
Utilized latent class modeling to analyze cognitive decline trajectories
Examined heterogeneity among individuals in preclinical stages of Alzheimer's
Focused on implications for the design of prevention trials.
Identified distinct trajectories of cognitive decline in preclinical Alzheimer's individuals
Demonstrated significant variability in decline patterns among participants
Highlighted that understanding these patterns can improve the design of prevention trials.

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Latent class modeling identifies cognitive decline patterns in preclinical Alzheimer's, suggesting tailored trial designs.

Latent class modeling reveals substantial heterogeneity in preclinical trajectories with important implications for prevention trial design.

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Li et al. (2026) studied this question.

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