Exposure to polylactic acid microplastics during puberty increases the risk of skeletal dysplasia by disrupting arachidonic acid metabolism in osteoblasts
Demonstrates skeletal dysplasia risk due to polylactic acid microplastics disrupting osteoblast metabolism in adolescents, suggesting need for interventions.
Key Points
The aim is to investigate the impact of polylactic acid microplastics on skeletal development in adolescent mice and understand the underlying mechanisms.
Evaluated skeletal toxicity of PLA-MPs in adolescent mice at environmentally relevant concentrations.
Conducted transcriptome analysis to examine metabolic disruptions in osteoblasts due to PLA-MPs exposure.
Assessed the protective effect of Ophiopogonin D on osteoblast differentiation and bone microstructure.
PLA-MPs treatment resulted in shortened body length and slowed femur and tibia growth in adolescent mice.
It caused significant damage to femoral microstructure and reduced trabecular bone formation.
Ophiopogonin D effectively alleviated the disruption in osteoblast differentiation associated with PLA-MPs exposure.