To explore the role of SPI1-driven POSTN transcription in esophageal cancer progression and macrophage behavior.
Examined SPI1 regulation of POSTN transcription in esophageal cancer cells.
Analyzed macrophage infiltration and polarization in response to POSTN signaling.
Investigated the implications for immunosuppressive environment in tumors.
SPI1 significantly promotes POSTN transcription in esophageal cancer cells.
Increased macrophage infiltration and immunosuppressive polarization were observed in the tumor microenvironment.
Findings suggest that targeting POSTN may provide a new therapeutic avenue for esophageal cancer.
Abstract
SPI1-driven POSTN transcription promotes EC cell growth and induces macrophage infiltration and immunosuppressive polarization, suggesting a new target for EC therapy.