Case report demonstrates significant pain reduction in head and neck cancer patients using subcutaneous Botox injections, indicating a new treatment option.
Patients with head and neck cancer commonly experience severe neuropathic pain. This pain is often challenging to treat and may be refractory to standard analgesic approaches. We describe the use of subcutaneous Botox injections to manage pain in such a patient. A patient with poorly differentiated carcinoma of the right base of skull with perineural invasion presented to the pain clinic with intractable facial pain. Subcutaneous Botox injections were performed. The patient experienced a significant reduction in the intensity of her pain following subcutaneous Botox injections. Subcutaneous Botox injections represent a safe and effective option for patients with head and neck cancer experiencing neuropathic pain refectory to standard analgesic medications.
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Davidson et al. (2026) studied this question.
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