mSphere of Influence: Host-pathogen interactions—the fascinating world of molecular interplay

Dilip Kumar is a structural biologist, working on developing novel antiviral strategies against pathogenic RNA viruses by using an integrated structural biology approach. In this mSphere of Influence article, he emphasizes how two remarkable research articles on host-pathogen interactions, "Inhibition of IRGM establishes a robust antiviral immune state to restrict pathogenic viruses" by P. Nath, N. R. Chauhan, K. K. Jena, A. Datey, et al. (EMBO Rep 22:EMBR202152948, 2021, https://doi.org/10.15252/embr.202152948), and "Cotranslational prolyl hydroxylation is essential for flavivirus biogenesis" by R. Aviner, K. H. Li, J. Frydman, and R. Andino (Nature, 596:558-564, 2021, https://doi.org/10.1038/s41586-021-03851-2), sparked his interest in pursuing host-pathogen interactions to develop a broad range of antiviral therapeutics.