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April 24, 2026BMC Pregnancy and ChildbirthOpen Access

Depression, anxiety, and stress across the perinatal period: longitudinal trends and associations with adverse outcomes

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Authors

MŽMarija ŽonjićVMVesna Mandić-MarkovićZPZorana Pavlović

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Overview

Prospective cohort study assesses trends of depression, anxiety, and stress in pregnant women, suggesting implications for maternal and neonatal outcomes.

Key Points

  • To assess the prevalence and longitudinal trends of depression, anxiety, and stress during the perinatal period and their associations with adverse outcomes.
  • Prospective cohort study involving 253 pregnant women tracked from early pregnancy to three months postpartum.
  • Psychological symptoms measured using the DASS-21 at five time points.
  • Data analyzed with linear mixed-effects models and logistic regression for outcome associations.
  • Depressive symptoms ranged from 4.5% to 9.9%, anxiety from 18.2% to 28.3%, and stress from 12.3% to 20.3% throughout the study.
  • Anxiety significantly declined after childbirth, while depressive symptoms remained stable.
  • No significant associations were noted for postpartum hemorrhage, small for gestational age, or gestational diabetes.

Cite This Study

Žonjić et al. (2026) studied this question.

synapsesocial.com/papers/69eb0bfa553a5433e34b573ahttps://doi.org/10.1186/s12884-026-09114-0
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