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Experimental model evaluates infection factors in individuals, suggesting insights into susceptibility variability.
A GMP-grade P. knowlesi YH1-HS parasite bank was successfully manufactured and shown to establish patent infection in humans. The finding that only one of two participants became infected at the highest inoculum dose highlights the potential for this IBSM model to evaluate factors influencing inter-individual variability in susceptibility to infection.
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Gower et al. (2026) studied this question.
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