Key result
Personalized clinical and population-based approaches must target high-CV-risk obesity forms including excess visceral fat.
Why the study?
Targeting obesity remains challenging partly because healthcare professionals tend to amalgamate all forms of obesity as a single entity despite it being a heterogeneous condition.
Recognizing the heterogeneity of obesity and targeting specific high-risk subgroups is essential for effective management in cardiovascular practice.
Supports phenotype-guided CV risk management targeting visceral fat and severe obesity; leaves open optimal personalized interventions pending randomized trials.
Obesity contributes to reduced life expectancy because of its link with type 2 diabetes and cardiovascular disease. Yet targeting this poorly diagnosed, ill-defined and under-addressed modifiable risk factor remains a challenge. In this review, we emphasize that the tendency among healthcare professionals to amalgam all forms of obesity altogether as a single entity may contribute to such difficulties and discrepancies. Obesity is a heterogeneous condition both in terms of causes and health consequences. Attention should be given to two prevalent subgroups of individuals: 1- patients who are overweight or moderately obese with excess visceral adipose tissue; and 2- patients with severe obesity, the latter group having distinct additional health issues related to their large body fat mass. The challenge of tackling high cardiovascular risk forms of obesity through a combination of personalized clinical approaches and population-based solutions is compounded by the current obesogenic environment and economy.
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Després et al. (2021) conducted a review in Obesity and cardiovascular disease. Management of obesity was evaluated. Obesity is a heterogeneous condition requiring personalized clinical approaches and population-based solutions to address high-cardiovascular-risk forms, particularly excess visceral fat and severe obesity.
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