Safety and Efficacy of Tranexamic Acid in Urologic Surgery: Results from the International, Randomized, Placebo-Controlled POISE-3 Trial

Key Points

To evaluate the safety and efficacy of tranexamic acid in preventing major bleeding during urologic surgery.
Conducted an international, randomized, placebo-controlled trial (POISE-3)
Assessed major bleeding in patients undergoing urologic surgery
Compared outcomes between tranexamic acid and placebo groups
Tranexamic acid reduced the occurrence of major bleeding compared to placebo.
The intervention was especially beneficial in surgeries with a high bleeding risk.

Randomized trial shows tranexamic acid reduces major bleeding in urologic surgery, suggesting safe perioperative use.

TXA reduced major bleeding and supports perioperative use in urologic surgery, especially when the bleeding risk is high.

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Tikkinen et al. (2026) studied this question.

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