Key result
CAD, PAD, and ischemic stroke share most genetic loci but maintain distinct disease-specific risk profiles.
Why the study?
The study was conducted to examine the shared and distinct genetic features of coronary artery disease, peripheral artery disease, and ischemic stroke.
Atherosclerotic cardiovascular diseases (CAD, PAD, IS) share etiologic genetic factors but also exhibit substantial disease-specific genetic differences.
Urges caution extrapolating CAD genetic insights to PAD or IS; leaves open distinct loci for targeted mechanistic research.
Aim of the studyTo study shared and distinct genetic features of coronary artery disease (CAD), peripheral artery disease (PAD), and ischemic stroke (IS).Main findings (A) Heritability was highest for CAD.(B) While the majority of risk loci overlapped, CAD, PAD and IS displayed many disease-specific loci.(C) Likewise, the genetic underpinnings of risk factors displayed markedly different effect sizes across the three diseases. ConclusionAtherosclerotic cardiovascular diseases share etiologic factors yet exhibit substantial genetic differences.
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Li et al. (2026) studied this question. Coronary artery disease, peripheral artery disease, and ischemic stroke share most genetic risk loci but exhibit many disease-specific loci and markedly different risk factor effect sizes.
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