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April 25, 2026International Journal of Hyperthermia0 citationsOpen Access

A study on the structural and magnetic properties of Fe 3 O 4 @SiO 2 core-shell microspheres along with a safety assessment in treating chemotherapy-resistant ovarian cancer

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HZHuanzhi ZhangYWYue WangYYYang Yang

Key Points

  • This research explores the properties of Fe3O4@SiO2 microspheres and assesses their safety in chemotherapy-resistant ovarian cancer treatment.
  • Core-shell structured Fe3O4@SiO2 nanocomposites were fabricated using coprecipitation and modified Stöber methods.
  • Both in vitro and in vivo experiments were conducted to evaluate the therapeutic effects and safety under magnetic induction.
  • In vitro and in vivo tests confirm good safety of Fe3O4@SiO2 nanocomposites for therapeutic use.
  • Magnetic fluid shows excellent therapeutic effect for treating chemotherapy-resistant ovarian cancer.

Abstract

Core-shell structured Fe3O4@SiO2 nanocomposites were fabricated through coprecipitation method and a modified Stöber approach, demonstrating monodisperse morphology and enhanced colloidal stability for biomedical applications. Both in vitro and in vivo experiments have confirmed that the magnetic fluid has good safety and excellent therapeutic effect under the magnetic induction coil.

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Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/69ec598788ba6daa22dab4c9https://doi.org/10.1080/02656736.2025.2610818
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