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April 25, 2026Journal of the American Chemical Society

Electroenzymatic C1 Fixation to Glycine via Dithiothreitol Regeneration on Functionalized 1T′-MoS 2

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Authors

ZZZixiao ZhaoJLJianming LiuJCJunxiang Chen

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Overview

Randomized trial investigates glycine production efficiency in integrating electrocatalysis and enzyme action, highlighting sustainable manufacturing methods.

Key Points

  • This research aims to develop an efficient electroenzymatic synthesis route for glycine from C1 feedstock.
  • Developed an electroenzymatic platform utilizing 1T'-MoS2 as an electrocatalyst.
  • Covalent functionalization of the catalyst enhanced performance for DTT regeneration.
  • Integrated the system with a downstream chemoenzymatic cascade for glycine synthesis.
  • Achieved a 2-fold enhancement in glycine production, reaching 12.2 mM over 9 hours.
  • Demonstrated fully biocompatible electrochemical regeneration of DTT.
  • Established a sustainable approach for C1 valorization through electrocatalytic and chemoenzymatic processes.

Cite This Study

Zhao et al. (2026) studied this question.

synapsesocial.com/papers/69ec598788ba6daa22dab5a1https://doi.org/10.1021/jacs.6c03530
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