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April 25, 2026Clinical Pharmacokinetics0 citationsOpen Access

Clinical Validation of Venetoclax Volumetric Microsampling in Patients with Leukemia with Assessment of Whole-Blood-to-Plasma Conversion Strategies and Self-Microsampling Feasibility

ALA. D. LevensJRJ. RijstenbilEME. Metscher

Key Points

  • The aim is to validate volumetric microsampling of venetoclax in leukemia patients and assess conversion strategies.
  • Evaluated capillary microsampling for venetoclax quantification in AML and CLL patients.
  • Applied individualized hematocrit-based conversion for accurate results.
  • Assessed home-based self-microsampling feasibility.
  • Both DBS and VAMS methods met international validation standards.
  • Self-microsampling at home proved feasible for patients.
  • Further studies are warranted to explore decentralized pharmacokinetics monitoring.

Abstract

Capillary microsampling enables accurate venetoclax quantification in patients with AML and CLL when individualized hematocrit-based microsample-to-plasma conversion is applied. Both DBS and VAMS met international validation criteria, and home-based self-microsampling proved feasible. Venetoclax home-based self-microsampling warrants further study as a tool for decentralized PK monitoring.

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Cite This Study

Levens et al. (2026) studied this question.

synapsesocial.com/papers/69ec59c688ba6daa22dab688https://doi.org/10.1007/s40262-026-01635-3
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