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April 25, 2026Chemical Reviews

Enzymatic Strategies for Nitrogen–Nitrogen Bond Formation in Natural Product Biosynthesis

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Authors

JSJingkun ShiGZGuiyun ZhaoYDYi‐Ling Du

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Overview

Review highlights enzymatic strategies forming N-N bonds in natural products, suggesting insights for biocatalyst development.

Key Points

  • The aim is to explore enzymatic strategies for forging nitrogen-nitrogen bonds in natural products.
  • Review of recent advances in genomics and biochemistry in nitrogen-nitrogen bond formation
  • Mechanistic elucidation of key enzyme families related to N-N bond synthesis
  • Summary of biosynthetic pathways of N-N-containing natural products.
  • Identification of enzyme families including heme-dependent hydrazine synthases and ATP-dependent diazotases.
  • Understanding of the catalytic logic of enzymes involved in N-N bond formation.
  • Foundation established for biocatalyst development and discovery of novel bioactive compounds.

Cite This Study

Shi et al. (2026) studied this question.

synapsesocial.com/papers/69ec59c688ba6daa22dab7b6https://doi.org/10.1021/acs.chemrev.5c01091
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