Demonstrates effective amide functionalization in diverse aromatic compounds, suggesting a sustainable pathway for drug development.
Direct decarbonylative triple C-N, C-C, and C-H functionalization of amides with hydrocarbons has been accomplished under mechanochemical conditions via Rh(I) catalysis. This method exhibits excellent substrate versatility in high-yielding couplings with diverse aromatic compounds, and its utility is highlighted by late-stage pharmaceutical derivatization and orthogonal C-X and C-N sequential cross-couplings. This solvent-free mechanochemical approach drastically lowers the temperature required for triple amide activation, overcoming kinetic barriers through a sustainable pathway.
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Zhang et al. (2026) studied this question.
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