New isohemigossypol related conjugates and caffeoylated oleanane triterpenoids from Hibiscus syriacus roots with anti-senescence modulating activity

Key Points

• The aim is to isolate new compounds from Hibiscus syriacus and evaluate their anti-senescence properties.
• Isolation of six isohemigossypol–phenylpropanoid conjugates and caffeoylated triterpenoids
• Evaluation of anti-senescence activity via suppression of cellular markers
• Assessment of effects on p16 INK4A and SASP cytokines
• Compounds 9 and 10 exhibited significant anti-senescence activity
• Suppression of p16 INK4A was observed with treated cells
• Reduction in SASP cytokines was noted in response to compounds 9 and 10.