Study reports distinct histological features in PLAG1-rearranged uterine mesenchymal tumours, suggesting a need for integrated diagnostic terms.
PLAG1-rearranged uterine mesenchymal tumours demonstrate notable morphologic heterogeneity, predominantly presenting as myxoid leiomyosarcoma. We recommend using the integrated diagnostic term 'PLAG1-rearranged uterine mesenchymal tumour with features of [specific morphology]' to capture both the genetic alteration and histologic spectrum, accompanied by a comment regarding the limited experience and potential for recurrence.
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Cai et al. (2026) studied this question.
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