What question did this study set out to answer?

To assess the prevalence of the CENP-F-like pattern in ANA tests and its associations with significant clinical conditions.

April 25, 20260 citations

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The Prevalence and Clinical Significance of the Centromere Protein-F-Like Immunofluorescence Staining Pattern in a Large ANA-positive Cohort.

ZSZhenzhen SuSichuan University FZFeng ZhangSichuan University LZLijing ZhangSichuan University

Key Points

To assess the prevalence of the CENP-F-like pattern in ANA tests and its associations with significant clinical conditions.
Analyzed a large cohort of ANA-positive individuals for the CENP-F-like immunofluorescence staining pattern.
Investigated the correlation between this pattern and the occurrence of cancers and autoimmune diseases (AIDs).
CENP-F-like pattern identified in a minority of ANA-positive individuals, with notable associations to metastasis (specific rates not detailed) and graft-versus-host disease (GVHD).
Concurrent autoantibodies were found to assist in diagnosing AIDs, indicating potential diagnostic value of this pattern.

Abstract

The CENP-F-like pattern is rare in ANA tests but may be associated with clinically important conditions, particularly cancers and AIDs. The occurrence of metastasis and GVHD in patients with this pattern highlights its potential clinical relevance, and concurrent autoantibodies may assist in diagnosing AIDs.

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The Prevalence and Clinical Significance of the Centromere Protein-F-Like Immunofluorescence Staining Pattern in a Large ANA-positive Cohort.

Key Points

Abstract

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