Compared to controls, the intervention group showed significantly greater improvements in global cognition (MMSE change, Cohen's d = 2.43; 95% CI: 1.40 to 3.44), quality of life (LEIPAD change, Cohen's d = 1.09; 95% CI: 0.40 to 1.76), and depressive symptoms (GDS change, Cohen's d = 2.07; 95% CI: 1.13 to 2.98). The intervention was well-tolerated, with high adherence and no reported adverse events.The CIMORGH package is feasible and highly effective in improving cognition, quality of life, and mood among illiterate older adults with MCI, with large between-group effect sizes.
Zendehbad et al. (2026) studied this question.