Synthesis of Organic HCl Salts via Mechanochemical Salification and their Characterization with 35/37 Cl Solid-State NMR Spectroscopy

Zachary Thomas Dowdell; Peyton G Osborn; Victoria K Rash; Trisha S Patel; Alexander Michael Perez; Xinsong Lin; Sean T. Holmes; Rob Schurko

doi:10.1039/d5mr00156k

January 1, 2026RSC MechanochemistryOpen Access

Synthesis of Organic HCl Salts via Mechanochemical Salification and their Characterization with 35/37 Cl Solid-State NMR Spectroscopy

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Key Points

The aim is to synthesize hydrochloride salts through mechanochemical salification and characterize their properties.
Utilized mechanochemical salification to produce hydrochloride salts.
Employed solid-state NMR spectroscopy for detailed characterization.
Assessed the physicochemical properties of the synthesized salts.
Demonstrated improved solubility and stability of hydrochloride salts compared to other forms.
Characterized structural features using <sup>35/37</sup> Cl solid-state NMR spectroscopy.
Highlighted the effectiveness of mechanochemical processes in synthesizing pharmaceutical salts.

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Implication

Assesses hydrochloride salt synthesis and characterization in pharmaceuticals, highlighting implications for API development.

Abstract

Hydrochloride (HCl) salts are among the most common solid forms of active pharmaceutical ingredients (APIs) because of their favorable physicochemical properties, including enhanced solubility and stability. However, their syntheses via...

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Dowdell et al. (2026) studied this question.

synapsesocial.com/papers/69ec5aa788ba6daa22dac2ae https://doi.org/10.1039/d5mr00156k

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Synthesis of Organic HCl Salts via Mechanochemical Salification and their Characterization with 35/37 Cl Solid-State NMR Spectroscopy

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Synthesis of Organic HCl Salts via Mechanochemical Salification and their Characterization with 35/37 Cl Solid-State NMR Spectroscopy

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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