Photocatalytic Regioselective Four-Component 1,4-Aryl Migration of N -Allylbenzamides To Access β-Arylethylamines

Radical-mediated rearrangement reactions serve as a powerful strategy for the construction of novel molecular frameworks. Herein, we report a photochemical four-component 1,4-aryl migration protocol for the highly regioselective synthesis of functionalized β-(hetero)arylethylamines. This practical approach employs readily accessible N-allylbenzamides and aryl thianthrenium salts, along with commercially available alcohols and (DABCO)·(SO₂)₂ (DABSO) as starting materials, and proceeds smoothly under mild reaction conditions. Moreover, this method tolerates a wide range of migratory aryl groups bearing diverse substitution patterns and electronic properties.